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Aspirin for Pain After all this time, no other OTC analgesic has been proven to be more effective than aspirin in relieving tough pain and, taken under a doctor's direction, reducing inflammation. Aspirin and Heart Disease Taken during a suspected heart attack, Bayer Aspirin can help save your life by reducing damage to your heart. Additionally, a low-dose aspirin regimen can help reduce your risk of a recurrent heart attack or ischemic stroke. Aspirin is not appropriate for everyone, so be sure to talk to your doctor before you begin an aspirin regimen. Bayer Aspirin Products No other over-the-counter pain reliever has been around as long or has been researched as extensively as aspirin, nor has any been proven to be more effective.